LOCUS       SEH5819                 1648 bp    DNA     linear   ROD 29-MAR-1999
DEFINITION  Spalax ehrenbergi gene encoding growth hormone.
ACCESSION   AJ005819
VERSION     AJ005819.1  GI:3116088
KEYWORDS    growth hormone; somatotropin.
SOURCE      Nannospalax ehrenbergi (Ehrenberg's mole-rat)
  ORGANISM  Nannospalax ehrenbergi
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Spalacinae;
            Nannospalax.
REFERENCE   1
  AUTHORS   Lioupis,A., Nevo,E. and Wallis,M.
  TITLE     Cloning and characterisation of the gene encoding mole rat (Spalax
            ehrenbergi) growth hormone
  JOURNAL   J. Mol. Endocrinol. 22 (1), 29-36 (1999)
  MEDLINE   99124645
   PUBMED   9924177
REFERENCE   2  (bases 1 to 1648)
  AUTHORS   Lioupis,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-APR-1998) Lioupis A., Biochemistry Laboratory, School
            of Biological Sciences, University of Sussex, Brighton, East
            Sussex, BN1 9QG, UK
FEATURES             Location/Qualifiers
     source          1..1648
                     /organism="Nannospalax ehrenbergi"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:30637"
                     /sex="male"
                     /note="chromosomal species 2n=60"
     mRNA            join(82..154,357..517,712..828,965..1126,1373..>1648)
     exon            82..154
                     /number=1
     CDS             join(145..154,357..517,712..828,965..1126,1373..1573)
                     /codon_start=1
                     /product="growth hormone"
                     /protein_id="CAA06716.1"
                     /db_xref="GI:3116089"
                     /db_xref="GOA:O70615"
                     /db_xref="SPTREMBL:O70615"
                     /translation="MATGSQTSWLLTFTLLCLPWPQEAGAFPAMPLSNLFANAVLRAQ
                     HLHQLAADTYKEFERAYIPEGQRYSIQNAQAAFCFSETIPAPTGKEEAQQRSDMELLR
                     FSLLLIQSWLGPVQFLSRVFTNSLVFGTSDRVFEKLKDLEEGIQALMRELEDGSLRAG
                     QLLKQTYDKFDTNMRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF"
     sig_peptide     join(145..154,357..424)
     mat_peptide     join(425..517,712..828,965..1126,1373..1570)
                     /product="growth hormone"
     intron          155..356
                     /number=1
     exon            357..517
                     /number=2
     intron          518..711
                     /number=2
     exon            712..828
                     /number=3
     intron          829..964
                     /number=3
     exon            965..1126
                     /number=4
     variation       1090
                     /note="silent allelic polymorphism"
                     /replace="t"
     intron          1127..1372
                     /number=4
     exon            1373..1648
                     /number=5
ORIGIN      
        1 gtcccatgaa tacatgtatg gggaaaatag gcagggggag aaccagccag ggtataaaaa
       61 gggcccacaa aggaccaact ccaggatcct aggacccaga tctccaaact gctcaggatc
      121 ctgtggacag ctcattccat gacaatggct acaggtgagc atccctaaaa tctctttggg
      181 tgtgatgtgg accgagagga gatgtacgag ttgaagatgg gtttgaggtt tctgatatga
      241 atacagccat ctaagcccaa cctttgccca tgttgagaac attctcagtt cctatgggga
      301 ttgggagaga ctgaccactg ctctcaggct tcccctgcct ccctgtcttt ctctaggctc
      361 tcagacctcc tggctcctga ccttcaccct gctctgcctg ccctggcctc aggaggctgg
      421 tgccttccct gccatgccct tgtccaatct gtttgccaac gctgtgctcc gagcccagca
      481 cctgcatcaa ctggctgctg atacctacaa agagtttgta agctccccaa agttgggtat
      541 ctggctgtgg tgagaggaag gggcagattc ccccctgaga cgtcatggga ggaaactcag
      601 gggaccaggg gtgtcttaaa caagtaaatg ctgtcaggtg agcagaaatc aagggagtct
      661 tcaaccaggt agtgatgaca gtctcagatc tcaacaactg tgctcctcta ggaacgtgcc
      721 tacatccccg agggacagcg atattccatc cagaacgccc aggctgcctt ctgcttctca
      781 gagaccatcc cggcccccac cggcaaggag gaggcccagc agagatccgt gagtggactc
      841 cgaggctttg tccacataca tcttttttcc ctccataaag ctccaactgt accccaggcc
      901 aggagccagc ttctccccag gcagagctca gcaggcaaca cacttactta acccttcctc
      961 acaggacatg gagctgctcc gcttctctct cctgctcatc cagtcgtggc tggggcccgt
     1021 gcagttcctc agcagggtct tcaccaacag cctggtattc ggcacctcgg accgcgtctt
     1081 tgagaaactg aaggacctgg aagaggggat ccaggctttg atgcgggtga gcatggcatg
     1141 gtgtccccag tcccggggcc atactgccct ttgcctctgt ctggatccta gctgggagct
     1201 ggtgtgaggg gtggatgact gctgtttctt gtactagtca ggccttgacc catgacaagt
     1261 catcttattt atttcccctt ttgaagctcc agcctttctc taagtcctgg aggagaggga
     1321 gggcagaaat cctaaaacgc ctctgcttct cctgctcctc cttccactgc aggagctgga
     1381 agatggcagt ctccgagctg ggcaactcct caagcaaacc tatgacaagt ttgacaccaa
     1441 catgcgcagc gatgacgcac tgctcaagaa ctatgggctg ctctcctgct tcaagaagga
     1501 cctgcacaag gctgagacct acctgcgggt catgaagtgt cgccgctttg tggaaagcag
     1561 ctgtgccttc tagccacaca gtaccgtatc tccatactcc cccagcacct ccctgtggca
     1621 aatgccactc ccgtgcaagc atccttgt
//
